Human BCS1L activation kit by CRISPRa

CAT#: GA100422

BCS1L CRISPRa kit - CRISPR gene activation of human BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCS1L
• Locus ID: 617
• Kit Components:

  GA100422G1, BCS1L gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100422G2, BCS1L gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100422G3, BCS1L gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001079866, NM_001257342, NM_001257343, NM_001257344, NM_004328, NM_001318836, NM_001320717
• Synonyms: BCS; BCS1; BJS; FLNMS; GRACILE; h-BCS; Hs.6719; MC3DN1; PTD
• Summary: 'This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Several alternatively spliced transcripts encoding two different isoforms have been described. [provided by RefSeq, Jan 2016]'