Human BLM activation kit by CRISPRa

CAT#: GA100438

BLM CRISPRa kit - CRISPR gene activation of human BLM RecQ like helicase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BLM
• Locus ID: 641
• Kit Components:

  GA100438G1, BLM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100438G2, BLM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100438G3, BLM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000057, NM_001287246, NM_001287247, NM_001287248, NM_001287248.2, NM_001287247.2, NM_001287246.2
• Synonyms: BS; RECQ2; RECQL2; RECQL3
• Summary: 'The Bloom syndrome is an autosomal recessive disorder characterized by growth deficiency, microcephaly and immunodeficiency among others. It is caused by homozygous or compound heterozygous mutation in the gene encoding DNA helicase RecQ protein on chromosome 15q26. This Bloom-associated helicase unwinds a variety of DNA substrates including Holliday junction, and is involved in several pathways contributing to the maintenance of genome stability. Identification of pathogenic Bloom variants is required for heterozygote testing in at-risk families. [provided by RefSeq, May 2020]'