Human Betacellulin (BTC) activation kit by CRISPRa

CAT#: GA100478

BTC CRISPRa kit - CRISPR gene activation of human betacellulin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BTC
• Locus ID: 685
• Kit Components:

  GA100478G1, Betacellulin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100478G2, Betacellulin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100478G3, Betacellulin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001316963, NM_001729
• Summary: 'This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015]'