Human C8 (C8G) activation kit by CRISPRa

CAT#: GA100511

C8G CRISPRa kit - CRISPR gene activation of human complement C8 gamma chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: C8G
• Locus ID: 733
• Kit Components:

  GA100511G1, C8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100511G2, C8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100511G3, C8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000606
• Synonyms: C8C
• Summary: 'The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]'