Human Calcitonin (CALCA) activation kit by CRISPRa

CAT#: GA100557

CALCA CRISPRa kit - CRISPR gene activation of human calcitonin related polypeptide alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CALCA
• Locus ID: 796
• Kit Components:

  GA100557G1, Calcitonin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100557G2, Calcitonin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100557G3, Calcitonin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033952, NM_001033953, NM_001741, NR_125898
• Synonyms: CALC1; CGRP; CGRP-I; CGRP1; CT; KC; PCT
• Summary: 'This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]'