Human Caldesmon (CALD1) activation kit by CRISPRa

CAT#: GA100560

CALD1 CRISPRa kit - CRISPR gene activation of human caldesmon 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CALD1
• Locus ID: 800
• Kit Components:

  GA100560G1, Caldesmon gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100560G2, Caldesmon gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100560G3, Caldesmon gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004342, NM_033138, NM_033139, NM_033140, NM_033157
• Synonyms: CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
• Summary: 'This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]'