Human Calreticulin (CALR) activation kit by CRISPRa

CAT#: GA100565

CALR CRISPRa kit - CRISPR gene activation of human calreticulin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CALR
• Locus ID: 811
• Kit Components:

  GA100565G1, Calreticulin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100565G2, Calreticulin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100565G3, Calreticulin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004343
• Synonyms: cC1qR; CRT; HEL-S-99n; RO; SSA
• Summary: 'Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]'