Human Calpain 3 (CAPN3) activation kit by CRISPRa

CAT#: GA100578

CAPN3 CRISPRa kit - CRISPR gene activation of human calpain 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CAPN3
• Locus ID: 825
• Kit Components:

  GA100578G1, Calpain 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100578G2, Calpain 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100578G3, Calpain 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000070, NM_024344, NM_173087, NM_173088, NM_173089, NM_173090, NM_212464, NM_212465, NM_212467, NR_027911, NR_027912
• Synonyms: CANP3; CANPL3; LGMD2; LGMD2A; nCL-1; p94
• Summary: 'Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]'