Human Caspase-7 (CASP7) activation kit by CRISPRa

CAT#: GA100593

CASP7 CRISPRa kit - CRISPR gene activation of human caspase 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASP7
• Locus ID: 840
• Kit Components:

  GA100593G1, Caspase-7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100593G2, Caspase-7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100593G3, Caspase-7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001227, NM_001267056, NM_001267057, NM_001267058, NM_033338, NM_033339, NM_033340, NM_001320911
• Synonyms: CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3
• Summary: 'This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]'