Human Caspase 9 (CASP9) activation kit by CRISPRa

CAT#: GA100595

CASP9 CRISPRa kit - CRISPR gene activation of human caspase 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASP9
• Locus ID: 842
• Kit Components:

  GA100595G1, Caspase 9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100595G2, Caspase 9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100595G3, Caspase 9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001229, NM_001278054, NM_032996, NR_102732, NR_102733
• Synonyms: APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56
• Summary: 'This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]'