Human Caveolin 2 (CAV2) activation kit by CRISPRa

CAT#: GA100602

CAV2 CRISPRa kit - CRISPR gene activation of human caveolin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CAV2
• Locus ID: 858
• Kit Components:

  GA100602G1, Caveolin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100602G2, Caveolin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100602G3, Caveolin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206747, NM_001206748, NM_001233, NM_198212
• Synonyms: CAV
• Summary: 'The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]'