Human CD1E activation kit by CRISPRa

CAT#: GA100641

CD1E CRISPRa kit - CRISPR gene activation of human CD1e molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CD1E
• Locus ID: 913
• Kit Components:

  GA100641G1, CD1E gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100641G2, CD1E gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100641G3, CD1E gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042583, NM_001042584, NM_001042585, NM_001042586, NM_001042587, NM_001185107, NM_001185108, NM_001185110, NM_001185112, NM_001185113, NM_001185114, NM_001185115, NM_030893
• Synonyms: CD1A; R2
• Summary: 'This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]'