Human LRBA activation kit by CRISPRa

CAT#: GA100702

LRBA CRISPRa kit - CRISPR gene activation of human LPS responsive beige-like anchor protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LRBA
• Locus ID: 987
• Kit Components:

  GA100702G1, LRBA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100702G2, LRBA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100702G3, LRBA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199282, NM_006726, NM_001367550, NM_001364905
• Synonyms: BGL; CDC4L; CVID8; LAB300; LBA
• Summary: 'The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]'