Human CDH12 activation kit by CRISPRa

CAT#: GA100724

CDH12 CRISPRa kit - CRISPR gene activation of human cadherin 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDH12
• Locus ID: 1010
• Kit Components:

  GA100724G1, CDH12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100724G2, CDH12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100724G3, CDH12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317227, NM_001317228, NM_004061, NM_001364105, NM_001364106, NM_001364109, NM_001364104, NM_001364107, NM_001364108
• Synonyms: CDHB
• Summary: 'This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]'