Human CDH18 activation kit by CRISPRa

CAT#: GA100729

CDH18 CRISPRa kit - CRISPR gene activation of human cadherin 18

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDH18
• Locus ID: 1016
• Kit Components:

  GA100729G1, CDH18 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100729G2, CDH18 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100729G3, CDH18 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001167667, NM_001291956, NM_001291957, NM_004934, NM_001349556, NM_001349558, NM_001349559, NM_001349560, NM_001349561, NM_001349562, NM_001349563, NM_001291956.3
• Synonyms: CDH14; CDH14L; CDH24
• Summary: 'This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]'