Human p57 Kip2 (CDKN1C) activation kit by CRISPRa

CAT#: GA100740

CDKN1C CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase inhibitor 1C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDKN1C
• Locus ID: 1028
• Kit Components:

  GA100740G1, p57 Kip2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100740G2, p57 Kip2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100740G3, p57 Kip2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000076, NM_001122630, NM_001122631, NM_001362474, NM_001362475
• Synonyms: BWCR; BWS; KIP2; p57; p57Kip2; WBS
• Summary: 'This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]'