Human CENPE activation kit by CRISPRa

CAT#: GA100766

CENPE CRISPRa kit - CRISPR gene activation of human centromere protein E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CENPE
• Locus ID: 1062
• Kit Components:

  GA100766G1, CENPE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100766G2, CENPE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100766G3, CENPE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286734, NM_001813, NM_001286734.2
• Synonyms: CENP-E; KIF10; MCPH13; PPP1R61
• Summary: 'Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]'