Human CENPF activation kit by CRISPRa

CAT#: GA100767

CENPF CRISPRa kit - CRISPR gene activation of human centromere protein F

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CENPF
• Locus ID: 1063
• Kit Components:

  GA100767G1, CENPF gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100767G2, CENPF gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100767G3, CENPF gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016343
• Synonyms: CENF; hcp-1; PRO1779
• Summary: 'This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]'