Human Cofilin 2 (CFL2) activation kit by CRISPRa

CAT#: GA100774

CFL2 CRISPRa kit - CRISPR gene activation of human cofilin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CFL2
• Locus ID: 1073
• Kit Components:

  GA100774G1, Cofilin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100774G2, Cofilin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100774G3, Cofilin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243645, NM_021914, NM_138638, NR_028130, NR_028131, NR_028132
• Synonyms: NEM7
• Summary: This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]