Human Muscarinic Acetylcholine Receptor M3 (CHRM3) activation kit by CRISPRa

CAT#: GA100808

CHRM3 CRISPRa kit - CRISPR gene activation of human cholinergic receptor muscarinic 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRM3
• Locus ID: 1131
• Kit Components:

  GA100808G1, Muscarinic Acetylcholine Receptor M3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100808G2, Muscarinic Acetylcholine Receptor M3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100808G3, Muscarinic Acetylcholine Receptor M3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000740, NM_001347716
• Synonyms: EGBRS; HM3
• Summary: 'The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]'