Human CHRNA3 activation kit by CRISPRa

CAT#: GA100813

CHRNA3 CRISPRa kit - CRISPR gene activation of human cholinergic receptor nicotinic alpha 3 subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRNA3
• Locus ID: 1136
• Kit Components:

  GA100813G1, CHRNA3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100813G2, CHRNA3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100813G3, CHRNA3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000743, NM_001166694, NR_046313
• Synonyms: LNCR2; NACHRA3; PAOD2
• Summary: 'This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]'