Human CHRNB1 activation kit by CRISPRa

CAT#: GA100817

CHRNB1 CRISPRa kit - CRISPR gene activation of human cholinergic receptor nicotinic beta 1 subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRNB1
• Locus ID: 1140
• Kit Components:

  GA100817G1, CHRNB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100817G2, CHRNB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100817G3, CHRNB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000747
• Synonyms: ACHRB; CHRNB; CMS1D; CMS2A; CMS2C; SCCMS
• Summary: 'The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]'