Human CHRNE activation kit by CRISPRa

CAT#: GA100822

CHRNE CRISPRa kit - CRISPR gene activation of human cholinergic receptor nicotinic epsilon subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRNE
• Locus ID: 1145
• Kit Components:

  GA100822G1, CHRNE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100822G2, CHRNE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100822G3, CHRNE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000080
• Synonyms: ACHRE; CMS1D; CMS1E; CMS2A; CMS4A; CMS4B; CMS4C; FCCMS; SCCMS
• Summary: 'Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]'