Human CLC7 (CLCN7) activation kit by CRISPRa

CAT#: GA100848

CLCN7 CRISPRa kit - CRISPR gene activation of human chloride voltage-gated channel 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLCN7
• Locus ID: 1186
• Kit Components:

  GA100848G1, CLC7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100848G2, CLC7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100848G3, CLC7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001114331, NM_001287
• Synonyms: CLC-7; CLC7; OPTA2; OPTB4; PPP1R63
• Summary: 'The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]'