Human CLK1 activation kit by CRISPRa

CAT#: GA100854

CLK1 CRISPRa kit - CRISPR gene activation of human CDC like kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLK1
• Locus ID: 1195
• Kit Components:

  GA100854G1, CLK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100854G2, CLK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100854G3, CLK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024646, NM_001162407, NM_004071, NR_027855, NR_027856
• Synonyms: CDC-like kinase 1; CDC28/CDC2-like kinase; CLK; CLK, STY, CLK/STY; CLK/STY; dual specificity protein kinase CLK1; protein tyrosine kinase STY; STY
• Summary: This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]