Human Carboxypeptidase H (CPE) activation kit by CRISPRa

CAT#: GA100953

CPE CRISPRa kit - CRISPR gene activation of human carboxypeptidase E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CPE
• Locus ID: 1363
• Kit Components:

  GA100953G1, Carboxypeptidase H gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100953G2, Carboxypeptidase H gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100953G3, Carboxypeptidase H gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001873
• Synonyms: CPH
• Summary: This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]