Human CRF1 (CRHR1) activation kit by CRISPRa

CAT#: GA100979

CRHR1 CRISPRa kit - CRISPR gene activation of human corticotropin releasing hormone receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CRHR1
• Locus ID: 1394
• Kit Components:

  GA100979G1, CRF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100979G2, CRF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100979G3, CRF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145146, NM_001145147, NM_001145148, NM_001303018, NM_001303020, NM_004382, NR_037772, NM_001303018.2
• Synonyms: CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L
• Summary: 'This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]'