Human p38 (CRK) activation kit by CRISPRa

CAT#: GA100983

CRK CRISPRa kit - CRISPR gene activation of human CRK proto-oncogene, adaptor protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CRK
• Locus ID: 1398
• Kit Components:

  GA100983G1, p38 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100983G2, p38 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100983G3, p38 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005206, NM_016823
• Synonyms: CRKII; p38
• Summary: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]