Human CRY2 activation kit by CRISPRa

CAT#: GA100990

CRY2 CRISPRa kit - CRISPR gene activation of human cryptochrome circadian regulator 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CRY2
• Locus ID: 1408
• Kit Components:

  GA100990G1, CRY2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100990G2, CRY2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100990G3, CRY2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127457, NM_021117
• Synonyms: HCRY2; PHLL2
• Summary: 'This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]'