Human CYP2C18 activation kit by CRISPRa

CAT#: GA101101

CYP2C18 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 2 subfamily C member 18

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP2C18
• Locus ID: 1562
• Kit Components:

  GA101101G1, CYP2C18 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101101G2, CYP2C18 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101101G3, CYP2C18 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000772, NM_001128925
• Synonyms: CPCI; CYP2C; CYP2C17; P450-6B/29C; P450IIC17
• Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'