Human Alpha Dystroglycan (DAG1) activation kit by CRISPRa

CAT#: GA101129

DAG1 CRISPRa kit - CRISPR gene activation of human dystroglycan 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DAG1
• Locus ID: 1605
• Kit Components:

  GA101129G1, Alpha Dystroglycan gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101129G2, Alpha Dystroglycan gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101129G3, Alpha Dystroglycan gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001165928, NM_001177634, NM_001177635, NM_001177636, NM_001177637, NM_001177638, NM_001177639, NM_001177640, NM_001177641, NM_001177642, NM_001177643, NM_001177644, NM_004393
• Synonyms: 156DAG; A3a; AGRNR; DAG; MDDGC7; MDDGC9
• Summary: 'This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]'