Human GADD45A activation kit by CRISPRa

CAT#: GA101162

GADD45A CRISPRa kit - CRISPR gene activation of human growth arrest and DNA damage inducible alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GADD45A
• Locus ID: 1647
• Kit Components:

  GA101162G1, GADD45A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101162G2, GADD45A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101162G3, GADD45A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199741, NM_001199742, NM_001924
• Synonyms: DDIT1; GADD45
• Summary: 'This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]'