Human Seladin 1 (DHCR24) activation kit by CRISPRa

CAT#: GA101193

DHCR24 CRISPRa kit - CRISPR gene activation of human 24-dehydrocholesterol reductase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DHCR24
• Locus ID: 1718
• Kit Components:

  GA101193G1, Seladin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101193G2, Seladin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101193G3, Seladin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014762
• Synonyms: DCE; Nbla03646; seladin-1; SELADIN1
• Summary: 'This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]'