Human Lipoamide Dehydrogenase (DLD) activation kit by CRISPRa

CAT#: GA101207

DLD CRISPRa kit - CRISPR gene activation of human dihydrolipoamide dehydrogenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DLD
• Locus ID: 1738
• Kit Components:

  GA101207G1, Lipoamide Dehydrogenase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101207G2, Lipoamide Dehydrogenase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101207G3, Lipoamide Dehydrogenase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000108, NM_001289750, NM_001289751, NM_001289752
• Synonyms: DLDD; DLDH; E3; GCSL; LAD; PHE3
• Summary: 'This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'