Human DSPP activation kit by CRISPRa

CAT#: GA101285

DSPP CRISPRa kit - CRISPR gene activation of human dentin sialophosphoprotein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DSPP
• Locus ID: 1834
• Kit Components:

  GA101285G1, DSPP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101285G2, DSPP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101285G3, DSPP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014208
• Synonyms: DFNA39; DGI1; DMP3; DPP; DSP; DTDP2
• Summary: 'This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jan 2016]'