Human Endothelin 2 (EDN2) activation kit by CRISPRa

CAT#: GA101328

EDN2 CRISPRa kit - CRISPR gene activation of human endothelin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EDN2
• Locus ID: 1907
• Kit Components:

  GA101328G1, Endothelin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101328G2, Endothelin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101328G3, Endothelin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302269, NM_001956, NR_126098
• Synonyms: ET-2; ET2; PPET2
• Summary: 'This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]'