Human Aminopeptidase A (ENPEP) activation kit by CRISPRa

CAT#: GA101409

ENPEP CRISPRa kit - CRISPR gene activation of human glutamyl aminopeptidase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ENPEP
• Locus ID: 2028
• Kit Components:

  GA101409G1, Aminopeptidase A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101409G2, Aminopeptidase A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101409G3, Aminopeptidase A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001977
• Synonyms: APA; CD249; gp160
• Summary: 'The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]'