Human EP300 activation kit by CRISPRa

CAT#: GA101412

EP300 CRISPRa kit - CRISPR gene activation of human E1A binding protein p300

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EP300
• Locus ID: 2033
• Kit Components:

  GA101412G1, EP300 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101412G2, EP300 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101412G3, EP300 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001429, N57495, NM_001362843
• Synonyms: KAT3B; p300; RSTS2
• Summary: 'This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]'