Human EYA4 activation kit by CRISPRa

CAT#: GA101447

EYA4 CRISPRa kit - CRISPR gene activation of human EYA transcriptional coactivator and phosphatase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EYA4
• Locus ID: 2070
• Kit Components:

  GA101447G1, EYA4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA101447G2, EYA4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA101447G3, EYA4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301012, NM_001301013, NM_004100, NM_172103, NM_172104, NM_172105, NM_001370458, NM_001370459
• Synonyms: CMD1J; DFNA10
• Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]