Human XPB (ERCC3) activation kit by CRISPRa

CAT#: GA101448

ERCC3 CRISPRa kit - CRISPR gene activation of human ERCC excision repair 3, TFIIH core complex helicase subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ERCC3
• Locus ID: 2071
• Kit Components:

  GA101448G1, XPB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101448G2, XPB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101448G3, XPB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000122, NM_001303416, NM_001303418
• Synonyms: BTF2; GTF2H; RAD25; TFIIH; TTD2; XPB
• Summary: 'This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]'