Human EVI1 (MECOM) activation kit by CRISPRa

CAT#: GA101479

MECOM CRISPRa kit - CRISPR gene activation of human MDS1 and EVI1 complex locus

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MECOM
• Locus ID: 2122
• Kit Components:

  GA101479G1, EVI1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101479G2, EVI1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101479G3, EVI1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001105077, NM_001105078, NM_001163999, NM_001164000, NM_001205194, NM_004991, NM_005241, NM_001366467, NM_001366469, NM_001366470, NM_001366471, NM_001366466, NM_001366468, NM_001366472, NM_001366473, NM_001366474
• Synonyms: AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3
• Summary: 'The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]'