Human MS4A2 activation kit by CRISPRa

CAT#: GA101544

MS4A2 CRISPRa kit - CRISPR gene activation of human membrane spanning 4-domains A2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MS4A2
• Locus ID: 2206
• Kit Components:

  GA101544G1, MS4A2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101544G2, MS4A2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101544G3, MS4A2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000139, NM_001142303, NM_001256916
• Synonyms: APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER; MS4A1
• Summary: 'The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]'