Human FES activation kit by CRISPRa

CAT#: GA101565

FES CRISPRa kit - CRISPR gene activation of human FES proto-oncogene, tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FES
• Locus ID: 2242
• Kit Components:

  GA101565G1, FES gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101565G2, FES gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101565G3, FES gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001143783, NM_001143784, NM_001143785, NM_002005
• Synonyms: FPS
• Summary: 'This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]'