Human FMRP (FMR1) activation kit by CRISPRa

CAT#: GA101639

FMR1 CRISPRa kit - CRISPR gene activation of human fragile X mental retardation 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FMR1
• Locus ID: 2332
• Kit Components:

  GA101639G1, FMRP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101639G2, FMRP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101639G3, FMRP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001185075, NM_001185076, NM_001185081, NM_001185082, NM_002024, NR_033699, NR_033700
• Synonyms: FMRP; FRAXA; POF; POF1; POFX
• Summary: 'The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]'