Human Folate Binding Protein (FOLR1) activation kit by CRISPRa

CAT#: GA101645

FOLR1 CRISPRa kit - CRISPR gene activation of human folate receptor alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FOLR1
• Locus ID: 2348
• Kit Components:

  GA101645G1, Folate Binding Protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101645G2, Folate Binding Protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101645G3, Folate Binding Protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000802, NM_016724, NM_016725, NM_016729, NM_016730, NM_016731
• Synonyms: FBP; FOLR
• Summary: 'The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]'