Human GDNF Receptor alpha 2 (GFRA2) activation kit by CRISPRa

CAT#: GA101787

GFRA2 CRISPRa kit - CRISPR gene activation of human GDNF family receptor alpha 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GFRA2
• Locus ID: 2675
• Kit Components:

  GA101787G1, GDNF Receptor alpha 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101787G2, GDNF Receptor alpha 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101787G3, GDNF Receptor alpha 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001165038, NM_001165039, NM_001495
• Synonyms: GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2
• Summary: 'Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]'