Human GRK4 activation kit by CRISPRa

CAT#: GA101928

GRK4 CRISPRa kit - CRISPR gene activation of human G protein-coupled receptor kinase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRK4
• Locus ID: 2868
• Kit Components:

  GA101928G1, GRK4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101928G2, GRK4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101928G3, GRK4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001004056, NM_001004057, NM_005307, NM_182982, NM_001350173
• Synonyms: GPRK2L; GPRK4; GRK4a; IT11
• Summary: 'This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]'