Human NMDAR1 (GRIN1) activation kit by CRISPRa

CAT#: GA101958

GRIN1 CRISPRa kit - CRISPR gene activation of human glutamate ionotropic receptor NMDA type subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRIN1
• Locus ID: 2902
• Kit Components:

  GA101958G1, NMDAR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101958G2, NMDAR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101958G3, NMDAR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000832, NM_001185090, NM_001185091, NM_007327, NM_021569
• Synonyms: GluN1; MRD8; NMD-R1; NMDA1; NMDAR1; NR1
• Summary: 'The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]'