Human Metabotropic Glutamate Receptor 1 (GRM1) activation kit by CRISPRa

CAT#: GA101966

GRM1 CRISPRa kit - CRISPR gene activation of human glutamate metabotropic receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRM1
• Locus ID: 2911
• Kit Components:

  GA101966G1, Metabotropic Glutamate Receptor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101966G2, Metabotropic Glutamate Receptor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101966G3, Metabotropic Glutamate Receptor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000838, NM_001114329, NM_001278064, NM_001278065, NM_001278066, NM_001278067
• Synonyms: GPRC1A; GRM1A; mGlu1; MGLUR1; MGLUR1A; SCAR13
• Summary: 'This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]'