Human Metabotropic Glutamate Receptor 5 (GRM5) activation kit by CRISPRa

CAT#: GA101970

GRM5 CRISPRa kit - CRISPR gene activation of human glutamate metabotropic receptor 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRM5
• Locus ID: 2915
• Kit Components:

  GA101970G1, Metabotropic Glutamate Receptor 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101970G2, Metabotropic Glutamate Receptor 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101970G3, Metabotropic Glutamate Receptor 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000842, NM_001143831
• Synonyms: GPRC1E; mGlu5; MGLUR5; PPP1R86
• Summary: 'This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]'